Fecal microbiome in dogs with lymphoid and nonlymphoid tumors.

ABSTRACT:

Background

The association of gut microbiota with cancer etiology and prognosis has been demonstrated in humans and rodents but has not been studied in dogs with different types of tumors.

Hypothesis/objectives

To analyze microbiome composition according to tumor progression based on metastasis, recurrence, and therapeutic response in canine tumors.

Animals

Thirty-two client-owned dogs were divided into 3 groups: healthy (n = 9), with lymphoma (n = 12), with nonlymphoid tumors (n = 11).

Methods

Retrospective case series included animals were divided into subgroups according to the nature and severity of their tumors. Feces were screened for the 16S rRNA gene.

Results

Overall, alpha diversity was significantly reduced in dogs with tumors (n = 23; 12 lymph

SUBMITTER: Bae H 

PROVIDER: S-EPMC10061189 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature