Dynamic Imine Bonding Facilitates Mannan Release from a Nanofibrous Peptide Hydrogel.

ABSTRACT: Recently, there has been increased interest in using mannan as an immunomodulatory bioconjugate. Despite notable immunological and functional differences between the reduced (R-Man) and oxidized (O-Man) forms of mannan, little is known about the impact of mannan oxidation state on its in vivo persistence or its potential controlled release from biomaterials that may improve immunotherapeutic or prophylactic efficacy. Here, we investigate the impact of oxidation state on the in vitro and in vivo release of mannan from a biocompatible and immunostimulatory multidomain peptide hydrogel, K₂(SL)₆K₂ (abbreviated as K₂), that has been previously used for the controlled release of protein and small molecule payloads. We observed that

SUBMITTER: Pogostin BH 

PROVIDER: S-EPMC10061233 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature