Age and Genetic Risk Score and Rates of Blood Lipid Changes in China.

ABSTRACT:

Importance

Blood lipids are the primary cause of atherosclerosis. However, little is known about relationships between rates of blood lipid changes and age and genetic risk.

Objective

To evaluate associations of blood lipid change rates with age and polygenic risk.

Design, setting, and participants

This cohort is from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China, which was established from 1998 to 2008. Participants were followed up until 2020 (mean [SD] follow-up, 13.8 [4.3] years) and received 4 repeated lipid measurements. Data analysis was performed from June to August 2022. A total of 47 691 participants with available genotype data were recruited, and 37 317 participants aged 18 years or older were included in the final analysis after

SUBMITTER: Li J 

PROVIDER: S-EPMC10061238 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature