Imaging phenotypes from MRI for the prediction of glioma immune subtypes from RNA sequencing: A multicenter study.

ABSTRACT: Tumor subtyping based on its immune landscape may guide precision immunotherapy. The aims of this study were to identify immune subtypes of adult diffuse gliomas with RNA sequencing data, and to noninvasively predict this subtype using a biologically interpretable radiomic signature from MRI. A subtype discovery dataset (n = 210) from a public database and two radiogenomic datasets (n = 130 and 55, respectively) from two local hospitals were included. Brain tumor microenvironment-specific signatures were constructed from RNA sequencing to identify the immune types. A radiomic signature was built from MRI to predict the identified immune subtypes. The pathways underlying the radiomic signature were identified to annotate their biological meanings. The reproducibility of the findings was ver

SUBMITTER: Duan J 

PROVIDER: S-EPMC10061289 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature