Genetic landscape and personalized tracking of tumor mutations in Vietnamese women with breast cancer.

ABSTRACT: Breast cancer is the leading cause of cancer death in Vietnamese women, but its mutational landscape and actionable alterations for targeted therapies remain unknown. After treatment, a sensitive biomarker to complement conventional imaging to monitor patients is also lacking. In this prospective multi-center study, 134 early-stage breast cancer patients eligible for curative-intent surgery were recruited. Genomic DNA from tumor tissues and paired white blood cells were sequenced to profile all tumor-derived mutations in 95 cancer-associated genes. Our bioinformatic algorithm was then utilized to identify top mutations for individual patients. Serial plasma samples were collected before surgery and at scheduled visits after surgery. Personalized assay tracking the selected mutations were p

SUBMITTER: Nguyen Hoang VA 

PROVIDER: S-EPMC10061293 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature