Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8⁺β7 integrin⁺ T cells and anti-SARS-CoV-2 IgA response.

ABSTRACT: Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent individuals with PASC compared to convalescent asymptomatic and uninfected participants, six months following their COVID-19 diagnosis. Both convalescent asymptomatic and PASC cases are characterised by higher CD8⁺ T cell percentages, however, the proportion of blood CD8⁺ T cells expressing the mucosal homing receptor β7 is low in PASC patients. CD8 T cells show increased expression of PD-1, perforin and granzyme B in PASC, and the plasma levels of type I and type III (mucosal) interferons are elevated. The humoral response is characterized by higher levels of IgA against

SUBMITTER: Santa Cruz A 

PROVIDER: S-EPMC10061413 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature