The metabolites of de novo NAD⁺ synthesis are a valuable predictor of acute kidney injury.

ABSTRACT:

Background

Acute kidney injury (AKI) is often iatrogenic and potentially preventable. Reduced renal nicotinamide adenine dinucleotide (NAD⁺) is reported to increase the susceptibility of AKI. The present study explored the predictive value of urinary de novo NAD⁺ synthetic metabolites for AKI using two independent cohorts.

Methods

The expression of de novo NAD⁺ synthetic enzymes in human kidney was examined by immunohistochemistry and single-cell transcriptomes. Urine samples were collected from two independent cohorts: the methotrexate (MTX) cohort with high-dose MTX treatment for lymphoma (n = 189) and the liver transplantation cohort with orthotopic liver transplantation (n = 49). Urinary metabolomics study of N

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10061430 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature