Optimal positive end-expiratory pressure obtained with titration of a fraction of inspiratory oxygen: a randomized controlled clinical trial.

ABSTRACT:

Background

Optimal intraoperative positive end-expiratory pressure (PEEP) improves patient outcomes. Pulse oximetry has been used to determine the lung opening and closing pressures. Therefore, we hypothesized that intraoperative optimal PEEP obtained by titrating inspiratory oxygen fraction (FiO₂) guided with pulse oximetry could improve perioperative oxygenation.

Methods

Forty-six males undergoing elective robotic-assisted laparoscopic prostatectomy were randomly assigned to either the optimal PEEP group (group O; n=23) or the fixed PEEP of 5 cmH₂O group (group C; n=23). Optimal PEEP, defined as the PEEP with the lowest FiO₂ or 0.21 to maintain SpO₂ greater than or equal to 95%, was obtained in both groups after placing the patie

SUBMITTER: Gao L 

PROVIDER: S-EPMC10061449 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature