Identification of CaMK4 as a sex-difference-related gene in knee osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a common degenerative joint disease with a higher prevalence in females than in males. Sex may be a key factor affecting the progression of OA. This study aimed to investigate critical sex-difference-related genes in patients with OA and confirm their potential roles in OA regulation.

Methods

OA datasets GSE12021, GSE55457, and GSE36700 were downloaded from the Gene Expression Omnibus database to screen OA-causing genes that are differentially expressed in the two sexes. Cytoscape was used to construct a protein-protein interaction network and determine hub genes. Synovial tissues of patients (male and female) with OA and female non-OA healthy controls were obtained to confirm the expression of hub genes and screen the key genes among them.

SUBMITTER: Feng C 

PROVIDER: S-EPMC10061463 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature