Healing mechanism of diabetic foot ulcers using single-cell RNA-sequencing.

ABSTRACT:

Background

Diabetic foot ulcer (DFU) is one of the common and severe complications in diabetic patients, mainly caused by the interaction of various factors such as peripheral neuropathy, peripheral vascular disease, and infection. Moreover, vascular damage, disorder of tissue cells, decreased expression level of neurotrophic factor, and decreased growth factor caused by long-term exposure to a high glucose environment can also lead to prolonged or incomplete wound healing. This imposes a tremendous financial burden on the patients' family and society. Although various innovative techniques and drugs have been developed to treat DFU, the therapeutic effect is still unsatisfactory.

Methods

We filtered and downloaded the single-cell dataset of diabetic patients from the Gene E

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10061471 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature