Early administration of mucoactive agents and ventilator-free days: a propensity score-matched study.

ABSTRACT:

Background

Mucoactive agents are often prescribed for the management of airway secretions. However, it is unclear whether they improve respiratory outcomes in mechanically ventilated patients.

Methods

We examined the association between the early administration of mucoactive agents in ventilated patients and increased ventilator-free days (VFDs). This retrospective observational study was conducted in two intensive care units (ICUs) of a tertiary care hospital in Japan. We applied 1:1 propensity score matching between the early mucoactive agent group and the on-demand mucoactive agent group. We compared VFDs during the first 28 days of ICU stay as the primary outcome between the groups.

Results

In total, 662 participants were eligible for this study, and 94 participan

SUBMITTER: Fujinaga J 

PROVIDER: S-EPMC10061474 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature