Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood.

ABSTRACT: We demonstrate proof-of-concept for point-of-care assessment of long-term alcohol consumption by measuring phosphatidylethanol in blood/dried blood spots with nano-electrospray ionization and MS/MS using a miniature mass spectrometer. 'Abstinence', 'moderate', and 'chronic' consumption could be distinguished rapidly for both sample types, and quantitative performance was obtained with blood (LoQ-100 ng mL^-1).

SUBMITTER: Pandey S 

PROVIDER: S-EPMC10061498 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature