Accessing Heteroannular Benzoxazole and Benzimidazole Scaffolds via Carbodiimides Using Azide-Isocyanide Cross-Coupling as Catalyzed by Mesoionic Singlet Palladium Carbene Complexes Derived from a Phenothiazine Moiety.

ABSTRACT: The coupling of aryl and aliphatic azides with isocyanides yielding carbodiimides (8-17) were efficiently catalyzed by well-defined structurally characterized trans-(MIC)PdI₂(L) [MIC = 1-CH₂Ph-3-Me-4-(CH₂N(C₆H₄)₂S)-1,2,3-triazol-5-ylidene, L = NC₅H₅ (4), MesNC (5)], trans-(MIC)₂PdI₂ (6), and cis-(MIC)Pd(PPh₃)I₂ (7) type palladium complexes, which incidentally mark the first instances of the use of mesoionic singlet palladium carbene complexes for the said application. As observed from the product yields, the catalytic activity varied in the order 4 > 5 ∼ 6 > 7 for these

SUBMITTER: Dey S 

PROVIDER: S-EPMC10061513 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature