Stratification of Companion Animal Life Stages from Electronic Medical Record Diagnosis Data.

ABSTRACT: Aging is a complex, multifactorial process, where different life stages reflect changes in metabolic processes, immune capacities, and genetic/epigenetic repertoires. With accumulating exposure to environmental stresses and deterioration of physiological functions, body systems become more prone to low-grade chronic inflammation and an increasing range of pathologies. We hypothesized that differential susceptibility to diseases across life span reflects phased changes in an organism's physiological capacity that may highlight when interventions may be appropriately used. Furthermore, the number of life stages may vary between species and be impacted by signalment such as breed. We tested this hypothesis using disease diagnoses data from veterinary electronic medical records containing almo

SUBMITTER: Salt C 

PROVIDER: S-EPMC10061556 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature