Emergency administration of fibrinogen concentrate for haemorrhage: systematic review and meta-analysis.

ABSTRACT:

Introduction

The occurrence of massive haemorrhages in various emergency situations increases the need for blood transfusions and increases the risk of mortality. Fibrinogen concentrate (FC) use may increase plasma fibrinogen levels more rapidly than fresh-frozen product or cryoprecipitate use. Previous several systematic reviews and meta-analyses have not effectively demonstrated FC efficacy in significantly improving the risk of mortality and reducing transfusion requirements. In this study, we investigated the use of FC for haemorrhages in emergency situations.

Methods and analysis

In this systematic review and meta-analysis, we included controlled trials, but excluded randomized controlled trials (RCTs) in elective surgeries. The study population consisted of patients wi

SUBMITTER: Itagaki Y 

PROVIDER: S-EPMC10061696 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature