DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites.

ABSTRACT:

Background

Cardiovascular disease (CVD) is the leading cause of death worldwide and considered one of the most environmentally driven diseases. The role of DNA methylation in response to the individual exposure for the development and progression of CVD is still poorly understood and a synthesis of the evidence is lacking.

Results

A systematic review of articles examining measurements of DNA cytosine methylation in CVD was conducted in accordance with PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines. The search yielded 5,563 articles from PubMed and CENTRAL databases. From 99 studies with a total of 87,827 individuals eligible for analysis, a database was created combining all CpG-, gene- and study-related information. It contains 74,580

SUBMITTER: Krolevets M 

PROVIDER: S-EPMC10061871 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature