Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline.

ABSTRACT:

Background

The impact of cardiovascular risk burden on cognitive trajectories and brain structure changes remains unclear.

Objectives

This study aimed to examine whether cardiovascular risk burden assessed by the Framingham General Cardiovascular Risk Score (FGCRS) is associated with cognitive decline and structural brain differences.

Methods

Within the Rush Memory and Aging Project, 1,588 dementia-free participants (mean age: 79.5 years) were followed for up to 21 years. FGCRS was assessed at baseline and categorized into tertiles (lowest, middle, and highest). Episodic memory, semantic memory, working memory, visuospatial ability, and perceptual speed were assessed annually with a battery of 19 tests, from which composite scores were derived. A subsample (n = 378) o

SUBMITTER: Song R 

PROVIDER: S-EPMC10061875 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature