Mesenchymal stromal cells modulate infection and inflammation in the uterus and mammary gland.

ABSTRACT: The use of mesenchymal stromal cells (MSCs) is emerging as an efficacious and safe treatment for many infectious and non-infectious inflammatory diseases in human and veterinary medicine. Such use could be done to treat mastitis and metritis, which are the most common disease conditions affecting dairy cows leading to considerable economic losses and reduced animal welfare. Currently, both disease conditions are commonly treated using local and systemic administration of antibiotics. However, this strategy has many disadvantages including low cure rates and the public health hazards. Looking for alternative approaches, we investigated the properties of MSCs using in-vitro mammary and endometrial cell systems and in-vivo mastitis and metritis murine model systems. In-vitro, co-culture of ma

SUBMITTER: Schouten I 

PROVIDER: S-EPMC10061880 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature