Identification of potential serum biomarkers for congenital heart disease children with pulmonary arterial hypertension by metabonomics.

ABSTRACT:

Background

Pulmonary arterial hypertension is a common complication in patients with congenital heart disease. In the absence of early diagnosis and treatment, pediatric patients with PAH has a poor survival rate. Here, we explore serum biomarkers for distinguishing children with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) from CHD.

Methods

Samples were analyzed by nuclear magnetic resonance spectroscopy-based metabolomics and 22 metabolites were further quantified by ultra-high-performance liquid chromatography-tandem mass spectroscopy.

Results

Serum levels of betaine, choline, S-Adenosyl methionine (SAM), acetylcholine, xanthosine, guanosine, inosine and guanine were significantly altered between CHD and PAH-CHD. Logistic regre

SUBMITTER: Jin N 

PROVIDER: S-EPMC10061882 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature