Septin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia.

ABSTRACT:

Background

Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking. Autoantibodies against septin-5 are associated with non-paraneoplastic cerebellar ataxia, and autoantibodies against septin-7 with encephalopathy with prominent neuropsychiatric features. Here, we report on newly identified autoantibodies against septin-3 in patients with paraneoplastic cerebellar ataxia. We also propose a strategy for anti-septin autoantibody determination.

Methods

Sera from three patients producing similar immunofluorescence staining patterns on cerebellar and hippocampal sections were subjected to immunoprecipitation followed by mass spectrometry. The identified can

SUBMITTER: Miske R 

PROVIDER: S-EPMC10061979 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature