Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.

ABSTRACT:

Purpose of review

This review aims to summarize the research on brain activity during affective processing (i.e., reward, negative emotional stimuli, loss) and adolescent substance use (SU).

Recent findings

Most research revealed links between altered neural activity in midcingulo-insular, frontoparietal and other network regions and adolescent SU. Increased recruitment of midcingulo-insular regions-particularly the striatum-to positive affective stimuli (e.g., monetary reward) was most often associated with initiation and low-level use of substances, whereas decreased recruitment of these regions was most often associated with SUD and higher risk SU. In regards to negative affective stimuli, most research demonstrated increased recruitment of midcingulo-insular network regi

SUBMITTER: Goncalves SF 

PROVIDER: S-EPMC10062006 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature