Computed tomography body composition and clinical outcomes following lung transplantation in cystic fibrosis.

ABSTRACT:

Background

Low muscle mass is common in patients approaching lung transplantation and may be linked to worse post-transplant outcomes. Existing studies assessing muscle mass and post-transplant outcomes include few patients with cystic fibrosis (CF).

Methods

Between May 1993 and December 2018, 152 adults with CF received lung transplants at our institution. Of these, 83 met inclusion criteria and had usable computed tomography (CT) scans. Using Cox proportional hazards regression, we evaluated the association between pre-transplant thoracic skeletal muscle index (SMI) and our primary outcome of death after lung transplantation. Secondary outcomes, including days to post-transplant extubation and post-transplant hospital and intensive care unit (ICU) length of stay, were asse

SUBMITTER: Jennerich AL 

PROVIDER: S-EPMC10062009 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature