DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer.

ABSTRACT:

Background

Few studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted age and chronological age, in relation to somatic genomic features in paired cancer and normal tissue, with less work done in non-European populations. In this study, we aimed to examine DNAm age and its associations with breast cancer risk factors, subtypes, somatic genomic profiles including mutation and copy number alterations and other aging markers in breast tissue of Chinese breast cancer (BC) patients from Hong Kong.

Methods

We performed genome-wide DNA methylation profiling of 196 tumor and 188 paired adjacent normal tissue collected from Chinese BC patients in Hong Kong (HKBC) using Illumina MethylationEPIC array. The DNAm age was calculated

SUBMITTER: Koka H 

PROVIDER: S-EPMC10062015 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature