Synchrotron-Based X-ray Fluorescence Imaging Elucidates Uranium Toxicokinetics in Daphnia magna.

ABSTRACT: A combination of synchrotron-based elemental analysis and acute toxicity tests was used to investigate the biodistribution and adverse effects in Daphnia magna exposed to uranium nanoparticle (UNP, 3-5 nm) suspensions or to uranium reference (U_ref) solutions. Speciation analysis revealed similar size distributions between exposures, and toxicity tests showed comparable acute effects (UNP LC₅₀: 402 μg L^-1 [336-484], U_ref LC₅₀: 268 μg L^-1 [229-315]). However, the uranium body burden was 3- to 5-fold greater in UNP-exposed daphnids, and analysis of survival as a function of body burden revealed a ∼5-fold higher specific toxicity from the U_ref exposure. High-resolution X-ray fluorescence elemental maps of intac

SUBMITTER: Byrnes I 

PROVIDER: S-EPMC10062025 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature