Recombinant Hexon Protein as a New Bovine Adenovirus Type 3 Subunit Vaccine Candidate.

ABSTRACT:

Introduction

Bovine adenovirus (BAdV) type 3 causes respiratory and gastroenteric diseases of varying severity in cattle, particularly newborn calves. Trials have been conducted of a vaccination against the diseases caused by BAdV using both modified live-virus and inactivated-virus preparations in cattle, but no commercial BAdV-3 vaccine has yet reached the market. Therefore, there is an urgent need to develop new, safe, and effective vaccines against BAdV-3.

Material and methods

Recombinant hexon protein (rhexon) of BAdV-3 was expressed in the E. coli system to evaluate immune response in mice and goats. Antibody responses and cytokine levels were analysed and the effects of administrations of different amounts of recombinant protein compared. Long-term antibody pro

SUBMITTER: Gundegmaa U 

PROVIDER: S-EPMC10062050 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature