Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLA^D/D Inbred Miniature Swine.

ABSTRACT: Xenotransplantation may compensate the limited number of human allografts for transplantation using pigs as organ donors. Porcine endogenous retroviruses inherit infectious potential if pig cells, tissues, or organs were transplanted to immunosuppressed human recipients. Particularly, ecotropic PERV-C that could recombine with PERV-A to highly replication-competent human-tropic PERV-A/C should be excluded from pig breeds designed for xenotransplantation. Because of their low proviral background, SLA^D/D (SLA, swine leukocyte antigen) haplotype pigs are potential candidates as organ donors as they do not bear replication-competent PERV-A and -B, even if they carry PERV-C. In this work, we characterized their PERV-C background isolating a full-length PERV-C proviral clone number 56

SUBMITTER: Rodrigues Costa M 

PROVIDER: S-EPMC10062142 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature