Perivascular adipose tissue promotes vascular dysfunction in murine lupus.

ABSTRACT:

Introduction

Patients with systemic lupus erythematosus (SLE) are at elevated risk for Q10 cardiovascular disease (CVD) due to accelerated atherosclerosis. Compared to heathy control subjects, lupus patients have higher volumes and densities of thoracic aortic perivascular adipose tissue (PVAT), which independently associates with vascular calcification, a marker of subclinical atherosclerosis. However, the biological and functional role of PVAT in SLE has not been directly investigated.

Methods

Using mouse models of lupus, we studied the phenotype and function of PVAT, and the mechanisms linking PVAT and vascular dysfunction in lupus disease.

Results and discussion

Lupus mice were hypermetabolic and exhibited partial lipodystrophy, with sparing of thoracic aortic PVA

SUBMITTER: Shi H 

PROVIDER: S-EPMC10062185 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature