Virome-wide detection of natural infection events and the associated antibody dynamics using longitudinal highly-multiplexed serology.

ABSTRACT: Current methods for detecting infections either require a sample collected from an actively infected site, are limited in the number of agents they can query, and/or yield no information on the immune response. Here we present an approach that uses temporally coordinated changes in highly-multiplexed antibody measurements from longitudinal blood samples to monitor infection events at sub-species resolution across the human virome. In a longitudinally-sampled cohort of South African adolescents representing >100 person-years, we identify >650 events across 48 virus species and observe strong epidemic effects, including high-incidence waves of Aichivirus A and the D68 subtype of Enterovirus D earlier than their widespread circulation was appreciated. In separate cohorts of adults who were sa

SUBMITTER: Kelley EJ 

PROVIDER: S-EPMC10062260 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature