Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure.

ABSTRACT:

Background

Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF remains largely unknown.

Objective

The purpose of this study was to investigate associations between serum-free thiol concentrations and disease severity and clinical outcome in patients with new-onset or worsening HF.

Methods

Serum-free thiol concentrations were determined by colorimetric detection in 3802 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF). Associations between free thiol concentrations and clinical characteristics and outcomes, including all-cause mortality, cardiovascular mortality, and a co

SUBMITTER: de Koning MLY 

PROVIDER: S-EPMC10062262 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature