Autoimmune diseases and new-onset atrial fibrillation: a UK Biobank study.

ABSTRACT:

Aims

The underlying mechanisms of atrial fibrillation (AF) are largely unknown. Inflammation may underlie atrial remodelling. Autoimmune diseases, related to increased systemic inflammation, may therefore be associated with new-onset AF.

Methods and results

Participants from the population-based UK Biobank were screened for rheumatic fever, gastrointestinal autoimmune diseases, autoimmune diseases targeting the musculoskeletal system and connective tissues, and neurological autoimmune diseases. Between 2006 and 2022, participants were followed for incident AF. Cox proportional hazards regression analyses were performed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) to quantify associations. 494 072 participants free from AF were included (median age 58.0

SUBMITTER: Tilly MJ 

PROVIDER: S-EPMC10062304 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature