M⁶A reader IGF2BP1 accelerates apoptosis of high glucose-induced vascular endothelial cells in a m⁶A-HMGB1 dependent manner.

ABSTRACT: Emerging evidence indicates that N⁶-methyladenosine (m⁶A) plays a critical role in vascular biological characteristic. In diabetes mellitus pathophysiology, high glucose (HG)-induced vascular endothelial dysfunction is associated with diabetes vascular complications. Nevertheless, the underlying mechanism of high glucose (HG)-related m⁶A regulation on vascular endothelial cells is still unclear. Results indicated that m⁶A reader insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) was up-regulated in HG-treated human umbilical vascular endothelium cells (HUVECs) comparing to normal group. Functionally, results indicated that IGF2BP1 knockdown recovered the proliferation of HUVECs inhibited by HG-administration. Besides, IGF2BP1 knockdown

SUBMITTER: Liang A 

PROVIDER: S-EPMC10062336 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature