Right ventricular epicardial arrhythmogenic substrate in long-QT syndrome patients at risk of sudden death.

ABSTRACT:

Aims

The long-QT syndrome (LQTS) represents a leading cause of sudden cardiac death (SCD). The aim of this study was to assess the presence of an underlying electroanatomical arrhythmogenic substrate in high-risk LQTS patients.

Methods and results

The present study enrolled 11 consecutive LQTS patients who had experienced frequent implantable cardioverter-defibrillator (ICD discharges triggered by ventricular fibrillation (VF). We acquired electroanatomical biventricular maps of both endo and epicardial regions for all patients and analyzed electrograms sampled from several myocardial regions. Abnormal electrical activities were targeted and eliminated by the means of radiofrequency catheter ablation. VF episodes caused a median of four ICD discharges in eleven patients (6 m

SUBMITTER: Pappone C 

PROVIDER: S-EPMC10062343 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature