Associations between resting state brain activity and A₁ adenosine receptor availability in the healthy brain: Effects of acute sleep deprivation.

ABSTRACT:

Introduction

Previous resting-state fMRI (Rs-fMRI) and positron emission tomography (PET) studies have shown that sleep deprivation (SD) affects both spontaneous brain activity and A₁ adenosine receptor (A₁AR) availability. Nevertheless, the hypothesis that the neuromodulatory adenosinergic system acts as regulator of the individual neuronal activity remains unexplored.

Methods

Therefore, fourteen young men underwent Rs-fMRI, A₁AR PET scans, and neuropsychological tests after 52 h of SD and after 14 h of recovery sleep.

Results

Our findings suggested higher oscillations or regional homogeneity in multiple temporal and visual cortices, whereas decreased oscillations in cerebellum after sleep loss. At the same time, we found that connect

SUBMITTER: Li C 

PROVIDER: S-EPMC10062390 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature