Metabolomic analysis of vascular cognitive impairment due to hepatocellular carcinoma.

ABSTRACT:

Introduction

Screening for metabolically relevant differentially expressed genes (DEGs) shared by hepatocellular carcinoma (HCC) and vascular cognitive impairment (VCI) to explore the possible mechanisms of HCC-induced VCI.

Methods

Based on metabolomic and gene expression data for HCC and VCI, 14 genes were identified as being associated with changes in HCC metabolites, and 71 genes were associated with changes in VCI metabolites. Multi-omics analysis was used to screen 360 DEGs associated with HCC metabolism and 63 DEGs associated with VCI metabolism.

Results

According to the Cancer Genome Atlas (TCGA) database, 882 HCC-associated DEGs were identified and 343 VCI-associated DEGs were identified. Eight genes were found at the intersection of these two gene sets: NNMT,

SUBMITTER: Zhu D 

PROVIDER: S-EPMC10062391 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature