Single-Atom Ce-N₄-C-(OH)₂ Nanozyme-Catalyzed Cascade Reaction to Alleviate Hyperglycemia.

ABSTRACT: The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment. However, research on alleviating metabolic diseases, such as hyperglycemia, has not been reported. Herein, we found that the single-atom Ce-N₄-C-(OH)₂ (SACe-N₄-C-(OH)₂) nanozyme promoted glucose absorption in lysosomes, resulting in increased reactive oxygen species production in HepG2 cells. Furthermore, the SACe-N₄-C-(OH)₂ nanozyme initiated a cascade reaction involving superoxide dismutase-, oxidase-, catalase-, and peroxidase-like activity to overcome the limitations associated with the substrate and produce •OH, thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein ki

SUBMITTER: Song G 

PROVIDER: S-EPMC10062498 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature