Ontology highlight
ABSTRACT:
SUBMITTER: Yeh SC
PROVIDER: S-EPMC10062553 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Yeh Shih-Chia SC Strilets Tania T Tan Wei-Lian WL Castillo David D Medkour Hacène H Rey-Cadilhac Félix F Serrato-Pomar Idalba M IM Rachenne Florian F Chowdhury Avisha A Chuo Vanessa V Azar Sasha R SR Singh Moirangthem Kiran MK Hamel Rodolphe R Missé Dorothée D Kini R Manjunatha RM Kenney Linda J LJ Vasilakis Nikos N Marti-Renom Marc A MA Nir Guy G Pompon Julien J Garcia-Blanco Mariano A MA
PLoS pathogens 20230330 3
Mosquito transmission of dengue viruses to humans starts with infection of skin resident cells at the biting site. There is great interest in identifying transmission-enhancing factors in mosquito saliva in order to counteract them. Here we report the discovery of high levels of the anti-immune subgenomic flaviviral RNA (sfRNA) in dengue virus 2-infected mosquito saliva. We established that sfRNA is present in saliva using three different methods: northern blot, RT-qPCR and RNA sequencing. We ne ...[more]