Acute chest syndrome, airway inflammation and lung function in sickle cell disease.

ABSTRACT:

Background

Acute chest syndrome (ACS) is an acute complication in SCD but its effects on lung function are not well understood. Inflammation is a key component of SCD pathophysiology but with an unclear association with lung function. We hypothesized that children with ACS had worse lung function than children without ACS and aimed to investigate the association of lung function deficits with inflammatory cytokines.

Methods

Patients enrolled in a previous 2-year randomized clinical trial who had consented to future data use, were enrolled for the present exploratory study. Patients were categorized into ACS and non-ACS groups. Demographic and clinical information were collected. Serum samples were used for quantification of serum cytokines and leukotriene B4 levels and pulmo

SUBMITTER: De A 

PROVIDER: S-EPMC10062579 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature