GATA-3 expression in breast cancer is related to intratumoral M2 macrophage infiltration and tumor differentiation.

ABSTRACT: Accumulating evidence indicates that tumor-associated macrophages promote tumor progression and that high macrophage infiltration is correlated with advanced tumor stages and poor prognosis in breast cancer. GATA binding protein 3 (GATA-3) is a differentiation marker related to differentiated states in breast cancer. In this study, we explore how the extent of MI relates to GATA-3 expression, hormonal status, and the differentiation grade of breast cancer. To examine breast cancer in early development, we selected 83 patients that were treated with radical breast-conserving surgery (R0), without lymph node metastases (N0) or distant metastases (M0), with and without postoperative radiotherapy. Immunostaining of M2-macrophage-specific antigen CD163 was used to detect tumor-associated macrop

SUBMITTER: Oda H 

PROVIDER: S-EPMC10062580 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature