Comprehensive analysis of m6A RNA methylation modification patterns and the immune microenvironment in osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is the most common joint degenerative disease, and so far, there is no effective therapy to prevent or delay its development. Considerable attention is now being given to the impact of m6A RNA methylation modification on the disease immune regulation. However, much remains unknown about the function of m6A modification in OA.

Methods

A total of 63 OA and 59 healthy samples were applied to comprehensively examine the m6A regulators mediated RNA methylation modification pattern in OA, and evaluate the impacts of distinct patterns on the characteristics of OA immune microenvironment, including immune infiltration cells, immune responses and human leukocyte antigen (HLAs) genes expression. In addition, we screened out the m6A phenotype-related gene

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10062708 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature