Estimating Temporally Variable Selection Intensity from Ancient DNA Data.

ABSTRACT: Novel technologies for recovering DNA information from archaeological and historical specimens have made available an ever-increasing amount of temporally spaced genetic samples from natural populations. These genetic time series permit the direct assessment of patterns of temporal changes in allele frequencies and hold the promise of improving power for the inference of selection. Increased time resolution can further facilitate testing hypotheses regarding the drivers of past selection events such as the incidence of plant and animal domestication. However, studying past selection processes through ancient DNA (aDNA) still involves considerable obstacles such as postmortem damage, high fragmentation, low coverage, and small samples. To circumvent these challenges, we introduce a novel Ba

SUBMITTER: He Z 

PROVIDER: S-EPMC10063216 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature