Longitudinal Reproducibility of MR Perfusion Using 3D Pseudocontinuous Arterial Spin Labeling With Hadamard-Encoded Multiple Postlabeling Delays.

ABSTRACT:

Background

Arterial spin labeling (ASL) can be confounded by varying arterial transit times (ATT) across the brain and with disease. Hadamard encoding schemes can be applied to 3D pseudocontinuous ASL (pCASL) to acquire ASL data with multiple postlabeling delays (PLDs) to estimate ATT and then correct cerebral blood flow (CBF).

Purpose

To assess the longitudinal reproducibility of 3D pCASL with Hadamard-encoded multiple PLDs.

Study type

Prospective, longitudinal.

Population

Fifty-two healthy, right-handed male subjects who underwent imaging at four timepoints over 45 days.

Field strength/sequence

A Hadamard-encoded 3D pCASL sequence was acquired at 3.0T with seven PLDs from 1.0-3.7 sec.

Assessment

ATT and corrected CBF (cCBF) were computed. Conven

SUBMITTER: Cohen AD 

PROVIDER: S-EPMC10063372 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature