Cervical body composition on radiotherapy planning computed tomography scans predicts overall survival in glioblastoma patients.

ABSTRACT:

Background and purpose

Glioblastoma (GBM) patients face a strongly unfavorable prognosis despite multimodal therapy regimens. However, individualized mortality prediction remains imprecise. Harnessing routine radiation planning cranial computed tomography (CT) scans, we assessed cervical body composition measures as novel biomarkers for overall survival (OS) in GBM patients.

Materials and methods

We performed threshold-based semi-automated quantification of muscle and subcutaneous fat cross-sectional area (CSA) at the levels of the first and second cervical vertebral body. First, we tested this method's validity by correlating cervical measures to established abdominal body composition in an open-source whole-body CT cohort. We then identified consecutive patients undergoing

SUBMITTER: Troschel FM 

PROVIDER: S-EPMC10063381 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature