Zwitterionic peptides: Tunable next-generation stealth nanoparticle modifications.

ABSTRACT: Adsorption of proteins to nanoparticles (NPs), a complex process that results in a protein corona, is controlled by NP surface properties that define NP interactions in vivo. Efforts to control adsorbed protein quantity through surface modification have led to improvements in circulation time or biodistribution. Still, current approaches have yet to be identified to control adsorbed protein identities within the corona. Here, we report the development and characterization of diverse zwitterionic peptides (ZIPs) for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP sequence. Through serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona, we determined that protein adsorption p

SUBMITTER: Overby C 

PROVIDER: S-EPMC10063383 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature