Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder.

ABSTRACT: Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for α-synucleinopathies. Overt α-synucleinopathies and aging share several mechanisms, but this relationship has been poorly investigated in prodromal phases. Using DNA methylation-based epigenetic clocks, we measured biological aging in videopolysomnography confirmed iRBD patients, videopolysomnography-negative and population-based controls. We found that iRBDs tended to be epigenetically older than controls, suggesting that accelerated aging characterizes prodromal neurodegeneration.

SUBMITTER: Baldelli L 

PROVIDER: S-EPMC10063653 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature