ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese.

ABSTRACT: Obesity has become a global health challenge also affecting reproductive health. In pregnant women, obesity increases the risk of complications such as preterm birth, macrosomia, gestational diabetes, and preeclampsia. Moreover, obesity is associated with long-term adverse effects for the offspring, including increased risk of cardiovascular and metabolic diseases and neurodevelopmental difficulties. The underlying mechanisms are far from understood, but placental function is essential for pregnancy outcome. Transporter proteins P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) are important for trans-placental transport of endogenous substances like lipids and cortisol, a key hormone in tissue maturation. They also hold a protective function protecting the fetus from xenob

SUBMITTER: Justesen S 

PROVIDER: S-EPMC10063677 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature