Kinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [¹⁸F]MK-6240 PET uptake.

ABSTRACT: [¹⁸F]MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We examined the kinetics and longitudinal changes of extracerebral and reference regions. [¹⁸F]MK-6240 PET was performed in 24 cognitively-normal and eight cognitively-impaired subjects, with arterial samples in 13 subjects. Follow-up scans at 6.1 ± 0.5 (n = 25) and 13.3 ± 0.9 (n = 16) months were acquired. Extracerebral and reference region (cerebellar gray matter (CerGM)-based, cerebral white matter (WM), pons) uptake were evaluated using standardized uptake values (SUV_90-110), spectral analysis, and distribution volume. Longitudinal changes in SUV_90-110 were examined. The impact of reference region on target region outcomes, partial volume correction (PVC) a

SUBMITTER: Fu JF 

PROVIDER: S-EPMC10063833 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature