Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen.

ABSTRACT: Functional magnetic resonance imaging (fMRI) is widely used by researchers to noninvasively monitor brain-wide activity. The traditional assumption of a uniform relationship between neuronal and hemodynamic activity throughout the brain has been increasingly challenged. This relationship is now believed to be impacted by heterogeneously distributed cell types and neurochemical signaling. To date, most cell-type- and neurotransmitter-specific influences on hemodynamics have been examined within the cortex and hippocampus of rodent models, where glutamatergic signaling is prominent. However, neurochemical influences on hemodynamics are relatively unknown in largely GABAergic brain regions such as the rodent caudate putamen (CPu). Given the extensive contribution of CPu function and dysfuncti

SUBMITTER: Katz BM 

PROVIDER: S-EPMC10063835 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature