Alterated gene expression in dilated cardiomyopathy after left ventricular assist device support by bioinformatics analysis.

ABSTRACT:

Introduction

Heart transplantation is the best treatment for end-stage dilated cardiomyopathy (DCM). Left ventricular assist device (LVAD) support is becoming more prevalent and may delay heart transplantation. Gene expression of the left ventricular myocardium usually changes following LVAD implantation. In this study, we aimed to identify potential biomarkers to determine the prognosis of patients with DCM after receiving LVAD support.

Methods

We extracted microarray datasets from Gene Expression Omnibus (GEO), including GSE430 and GSE21610. There were 28 paired DCM samples in the GSE430 and GSE21610 profiles. Differentially expressed genes (DEGs) were identified at LVAD implantation and heart transplantation. DEGs were annotated according to Gene Ontology (GO) and analyze

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10063844 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature