Chromosome 1 trisomy confers resistance to aureobasidin A in Candida albicans.

ABSTRACT:

Introduction

Candida albicans is a prevalent opportunistic human fungal pathogen. However, there are currently very few antifungal treatments available. Inositol phosphoryl ceramide synthase is an essential and fungal-specific protein that also provides a novel and promising antifungal target. Aureobasidin A is a widely used inhibitor of inositol phosphoryl ceramide synthase, however the mechanism of resistance to aureobasidin A is largely unknown in pathogenic fungi.

Methods

Here we investigated how C. albicans adapted to low and high concentrations of aureobasidin A.

Results and discussions

We identified trisomy of chromosome 1 as the predominant mechanism of rapid adaptation. Resistance to aureobasidin A was unstable because of the inherent instabilit

SUBMITTER: Zheng L 

PROVIDER: S-EPMC10063858 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature