A novel nomogram predicting the early recurrence of hepatocellular carcinoma patients after R0 resection.

ABSTRACT:

Background

Early tumor recurrence is one of the most significant poor prognostic factors for patients with HCC after R0 resection. The aim of this study is to identify risk factors of early recurrence, in addition, to develop a nomogram model predicting early recurrence of HCC patients.

Methods

A total of 481 HCC patients after R0 resection were enrolled and divided into a training cohort (n = 337) and a validation cohort (n = 144). Risk factors for early recurrence were determined based on Cox regression analysis in the training cohort. A nomogram incorporating independent risk predictors was established and validated.

Results

Early recurrence occurred in 37.8% of the 481 patients who underwent curative liver resection of HCC. AFP ≥ 400 ng/mL (HR: 1.662; P = 0.008),

SUBMITTER: Wang H 

PROVIDER: S-EPMC10063973 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature